Castiel and Uriel appear and demand that Sam and Dean hand over Anna, with Castiel announcing, "We're here for Anna...she has to die." Castiel states that Anna is far from innocent. The boys protest but the angels attack. Suddenly a bright light engulfs them and the angels are repelled and disappear. Sam and Dean go to the room where Anna was hiding, and find that she has used her blood to draw symbols on a mirror for a spell against the angels.

Uriel and Castiel reappear from being banished to take Anna. Dean's choice is revealed: either Anna dies - or Sam. As the angels are about to take her, an injured Ruby appears with Alastair. The demons and angels confront each other and another fight ensues. During the confrontation Castiel faces off with Alastair, landing several blows and tries to cast the demon back into the Pit. It proves ineffective and Alastair pins Castiel to the ground, strangles him and starts a demonic chant. Castiel is saved from Alastair's grip after Dean hits the demon across the back with a tire iron and distracts him from Castiel.

During the fight, Anna steals her Grace from Uriel and becomes an angel again. During the process, Alastair disappears. Uriel and Castiel leave, and we find out that it was Sam's plan all along to bring the demons and angels together to get them to fight each other.