In the first scene, Castiel finds an angel from his garrison dead.

Castiel and Uriel then appear in the Winchesters' hotel room, explaining to Dean that his torcher methods learnt in Hell were required on Alastair to find out which demon was killing the angels. Both Uriel and Castiel, after hearing that Dean does not want to go, take Dean to the place they were keeping Alastair.

Castiel tells Dean how his emotions are impairing his judgement, resulting in Uriel being placed in charge. He then tells Dean how the angels need, rather then want, him to do this.

Anna attempts to tell Castiel that forcing Dean into torchering again is morally wrong. However, Castiel is convinced his 'superiors' are correct.

After Alastair is freed from Devil's trap and beats Dean, Castiel tries to fight him. Alastair attempts to chant a Demonic spell to send Castiel back to Heaven but Sam interrupts him, using his demonic powers, saving Castiel.

Castiel confronts Sam outside Dean's hospital room. Sam assures Castiel that the Alastair was not lying, that the demons weren't the ones killing the angels.

Uriel and Castiel meet at a playground at talk about how 'something is wrong'. Castiel calls Anna and tells her that he is considering disobedience, however he does not believe it is 'good'.

Castiel finds out that a leaky pipe enabled Alastair to escape from his Devil's trap. Uriel confronts him and informs him that he was responsible for the death of the angels in their garrison and that he wishes Lucifer to rise and humanity to be destroyed. After Uriel's failed recruition, Castiel attacks Uriel. However, Uriel is too strong. Anna kills Uriel just before he tries to kill Castiel.

Castiel visits Dean in hospital and confirms that Dean's actions in Hell resulted in the breaking of the first seal. He also informs Dean that he is the only one that can finish it, that can stop Lucifer and the Apocalypse.